Speaker
Description
Background –
PCOS is a complex condition with reproductive, endocrine and metabolic characteristics. For its diagnosis, Rotterdam Criteria is used : 2 of 3 criteria should be present-
• Oligomenorrhea/ Amenorrhea
• Biochemical or clinical signs of hyperandrogenism
• Polycystic ovaries with >20 follicles in ovary or ovarian volume >10cc
**Irisin** is a newly discovered peptide hormone , a cleavage product of fibronectin type III domain 5 (FNDC5) , which consists of 212 amino acid residues. During exercise, irisin is secreted by skeletal muscle where it converts white adipose tissue to brown adipose tissue and produces thermogenesis.
Aims & objectives-
- To determine Serum Irisin levels in cases with PCOS and healthy controls
-To compare Serum Irisin levels in cases with PCOS and healthy controls
Setting: Dr BRAMH, Raipur , OPD patients
Method- Total 90 patients, out of this 30 Obese PCOS patients, 30 non-obese PCOS patients and 30 healthy controls. Participants 2ml fasting blood sample was taken for estimation of Irisin ,by commercially available ELISA kit . Anthropometric measurements taken and hormonal profile also evaluated.
Results- In our study Polycystic ovary syndrome women showed different body compositions compared with controls(non- PCOS). Serum irisin level of PCOS did not show significant difference compared with controls.Irisin maybe raised in obese PCOS patients as compared to non obese PCOS.
